Article
Tight junction defects in patients with atopic dermatitis.
The Journal of allergy and clinical immunology - 1 Mar 2011
De Benedetto Anna, Rafaels Nicholas M, McGirt Laura Y, Ivanov Andrei I, Georas Steve N, Cheadle Chris, Berger Alan E, Zhang Kunzhong, Vidyasagar Sadasivan, Yoshida Takeshi, Boguniewicz Mark, Hata Tissa, Schneider Lynda C, Hanifin Jon M, Gallo Richard L, Novak Natalija, Weidinger Stephan, Beaty Terri H, Leung Donald Y M, Barnes Kathleen C, Beck Lisa A
Abstract excerpt
BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive immune response to allergens, 2 cardinal features that are caused in part by epidermal barrier defects. Tight junctions (TJs) reside immediately below the stratum corneum and regulate the selective permeability of t...
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