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Article

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice.

The Journal of cell biology - 18 Mar 2002

Furuse Mikio, Hata Masaki, Furuse Kyoko, Yoshida Yoko, Haratake Akinori, Sugitani Yoshinobu, Noda Tetsuo, Kubo Akiharu, Tsukita Shoichiro

Abstract excerpt

The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier function of simple epithelia, but TJs have not been thought to play an important role in the barrier function of mammalian stratified epithelia, including the epidermis. Here we generated claudin-1-defic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11889141
DOI: 10.1083/jcb.200110122
PMCID: PMC2173463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11889141-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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