Article
Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations.
International journal of molecular sciences - 5 Nov 2019
Seker Murat, Fernandez-Rodriguez Carmen, Martinez-Cruz Luis Alfonso, Müller Dominik
Abstract excerpt
In higher organisms, epithelia separate compartments in order to guarantee their proper function. Such structures are able to seal but also to allow substances to pass. Within the paracellular pathway, a supramolecular structure, the tight junction transport is largely controlled by the temporospatial regulation of its major protein family called claudins. Besides the fact that the expression of claudins has been...
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