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Article

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.

International journal of epidemiology - 1 Oct 2016

Swerdlow Daniel I, Kuchenbaecker Karoline B, Shah Sonia, Sofat Reecha, Holmes Michael V, White Jon, Mindell Jennifer S, Kivimaki Mika, Brunner Eric J, Whittaker John C, Casas Juan P, Hingorani Aroon D

Abstract excerpt

Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that instrument these exposures. The approach is gaining popularity-our systematic review reveals a greater than 10-fold increase in MR studies published between 2004 and 2015. When the MR paradigm was first proposed, few biomarker- or exposure-related genetic...

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Identifiers

PMID: 27342221
DOI: 10.1093/ije/dyw088
PMCID: PMC5100611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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