Article
Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2016
Kiranmayi Malapaka, Chirasani Venkat R, Allu Prasanna K R, Subramanian Lakshmi, Martelli Elizabeth E, Sahu Bhavani S, Vishnuprabu Durairajpandian, Kumaragurubaran Rathnakumar, Sharma Saurabh, Bodhini Dhanasekaran, Dixit Madhulika, Munirajan Arasambattu K, Khullar Madhu, Radha Venkatesan, Mohan Viswanathan, Mullasari Ajit S, Naga Prasad Sathyamangla V, Senapati Sanjib, Mahapatra Nitish R
Abstract excerpt
Catestatin (CST), an endogenous antihypertensive/antiadrenergic peptide, is a novel regulator of cardiovascular physiology. Here, we report case-control studies in 2 geographically/ethnically distinct Indian populations (n≈4000) that showed association of the naturally-occurring human CST-Gly364Ser variant with increased risk for hypertension (age-adjusted odds ratios: 1.483; P=0.009 and 2.951; P=0.005)....
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