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Article

Chromogranin A polymorphisms are associated with hypertensive renal disease.

Journal of the American Society of Nephrology : JASN - 1 Mar 2008

Salem Rany M, Cadman Peter E, Chen Yuqing, Rao Fangwen, Wen Gen, Hamilton Bruce A, Rana Brinda K, Smith Douglas W, Stridsberg Mats, Ward Harry J, Mahata Manjula, Mahata Sushi K, Bowden Donald W, Hicks Pamela J, Freedman Barry I, Schork Nicholas J, O'Connor Daniel T

Abstract excerpt

Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells. Specific endopeptidases cleave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits catecholamine release. Previous studies have suggested that a deficit in this sympathetic "braking" system might be an early event in the pathogenesis of human hypertension. Whether...

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Source

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Identifiers

PMID: 18235090
DOI: 10.1681/ASN.2007070754
PMCID: PMC2391050

Genes

CHGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Chromogranin A polymorphisms are associated with hypertensive renal disease.PMID 18235090Read ↗

Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.Semantic proximity Read ↗

Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.Semantic proximity Read ↗

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.Semantic proximity Read ↗

Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107.Semantic proximity Read ↗

Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension.Semantic proximity Read ↗

A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders.Semantic proximity Read ↗

A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population.Semantic proximity Read ↗

Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.Semantic proximity Read ↗

Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.Semantic proximity Read ↗

Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension.Semantic proximity Read ↗

Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway.Semantic proximity Read ↗

Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis.Semantic proximity Read ↗

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