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Article

Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin.

Endocrinology - 1 Feb 2008

Biswas Nilima, Vaingankar Sucheta M, Mahata Manjula, Das Madhusudan, Gayen Jiaur R, Taupenot Laurent, Torpey Justin W, O'Connor Daniel T, Mahata Sushil K

Abstract excerpt

The plasma level of chromogranin A (CgA) is elevated in genetic hypertension. Conversely, the plasma level of the CgA peptide catestatin is diminished in individuals with established hypertension and those with a genetic risk of this disease. Resequencing of the human CHGA gene identified three naturally occurring variants of catestatin (Gly364Ser, Pro370Leu, and Arg374Gln) that exhibit different potencies in...

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Source

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Identifiers

PMID: 17991725
DOI: 10.1210/en.2007-0838
PMCID: PMC2219303

Genes

CHGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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