Article
Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?
Reproductive toxicology (Elmsford, N.Y.) - 1 Aug 2016
Godschalk Roger W L, Vanhees Kimberly, Maas Lou, Drittij Marie-Jose, Pachen Daniëlle, van Doorn-Khosrovani Sahar van Waalwijk, van Schooten Frederik J, Haenen Guido R M M
Abstract excerpt
A balanced redox homeostasis in the testis is essential for genetic integrity of sperm. Reactive oxygen species can disturb this balance by oxidation of glutathione, which is regenerated using NADPH, formed by glucose-6-phosphate dehydrogenase (G6PDH). G6PDH is regulated by the Ataxia Telangiectasia Mutated (Atm) protein. Therefore, we studied the redox status and DNA damage in testes and sperm of mice that...
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