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Article

ATM activation by oxidative stress.

Science (New York, N.Y.) - 22 Oct 2010

Guo Zhi, Kozlov Sergei, Lavin Martin F, Person Maria D, Paull Tanya T

Abstract excerpt

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates signaling cascades that initiate the DNA damage response. Cells lacking ATM are also hypersensitive to insults other than D...

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Source

Identifiers

PMID: 20966255
DOI: 10.1126/science.1192912

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20966255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.Semantic proximity Read ↗

ATM directs DNA damage responses and proteostasis via genetically separable pathways.Semantic proximity Read ↗

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ATM kinase: Much more than a DNA damage responsive protein.Semantic proximity Read ↗

Oxidative stress in ataxia telangiectasia.Semantic proximity Read ↗

Pathogenesis of ataxia-telangiectasia: the next generation of ATM functionsSemantic proximity Read ↗

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.Semantic proximity Read ↗

DNA Damage Responses: Mechanisms and Roles in Human DiseaseSemantic proximity Read ↗

Cell Death and Survival Pathways Involving ATM Protein KinaseSemantic proximity Read ↗

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large OrchestraSemantic proximity Read ↗

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