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Article

Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice.

Free radical biology & medicine - 1 Jan 2000

George Sunil K, Jiao Yan, Bishop Colin E, Lu Baisong

Abstract excerpt

Mitochondrial reactive oxygen species (ROS) have been implicated in spermatogenic damage, although direct in vivo evidence is lacking. We recently generated a mouse in which the inner mitochondrial membrane peptidase 2-like (Immp2l) gene is mutated. This Immp2l mutation impairs the processing of signal peptide sequences from mitochondrial cytochrome c₁ and glycerol phosphate dehydrogenase 2. The mitochondria from...

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Identifiers

PMID: 22569411
DOI: 10.1016/j.freeradbiomed.2012.04.003
PMCID: PMC3377857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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