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Article

ATM activation in the presence of oxidative stress.

Cell cycle (Georgetown, Tex.) - 15 Dec 2010

Guo Zhi, Deshpande Rajashree, Paull Tanya T

Abstract excerpt

The Ataxia-Telangiectasia mutated (ATM) kinase is regarded as the major regulator of the cellular response to DNA double strand breaks (DSBs). In response to DSBs, ATM dimers dissociate into active monomers in a process promoted by the Mre11-Rad50-Nbs1 (MRN) complex. ATM can also be activated by oxidative stress directly in the form of exposure to H2O2. The active ATM in this case is a disulfide-crosslinked dimer...

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Source

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Identifiers

PMID: 21150274
DOI: 10.4161/cc.9.24.14323
PMCID: PMC3047807

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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