Article
Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation.
Mutation research - 1 Mar 2007
Baulch Janet E, Li Ming-Wen, Raabe Otto G
Abstract excerpt
The ataxia telangiectasia mutated (ATM) gene product maintains genome integrity and initiates cellular DNA repair pathways following exposures to genotoxic agents. ATM also plays a significant role in meiotic recombination during spermatogenesis. Fertilization with sperm carrying damaged DNA could lead to adverse effects in offspring including developmental defects or increased cancer susceptibility. Currently,...
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