Article
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
Science signaling - 10 Jul 2018
Zhang Yichong, Lee Ji-Hoon, Paull Tanya T, Gehrke Sarah, D'Alessandro Angelo, Dou Qianhui, Gladyshev Vadim N, Schroeder Elizabeth A, Steyl Samantha K, Christian Brooke E, Shadel Gerald S
Abstract excerpt
Mitochondria are integral to cellular energy metabolism and ATP production and are involved in regulating many cellular processes. Mitochondria produce reactive oxygen species (ROS), which not only can damage cellular components but also participate in signal transduction. The kinase ATM, which is mutated in the neurodegenerative, autosomal recessive disease ataxia-telangiectasia (A-T), is a key player in the...
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