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Regulation of the Epigenome by Vitamin C

14 May 2015

Abstract excerpt

Emerging evidence suggests that ascorbate, the dominant form of vitamin C under physiological pH conditions, influences activity of the genome via regulating epigenomic processes. Ascorbate serves as a cofactor for Ten-eleven translocation (TET) dioxygenases that catalyze the oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and further to 5-formylcytosine (5fC) and to 5-carboxylcytosine...

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PMID: 25974700
DOI: 10.1146/annurev-nutr-071714-034228

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