Article

Essential role for Ggct in erythrocyte antioxidant defense

2021-06-22

Abstract excerpt

GGCT encodes γ-glutamyl cyclotransferase enzyme activity, and its expression is up-regulated in various human cancers. γ-glutamyl cyclotransferase enzyme activity was originally purified from human red blood cells (RBCs), however physiological function of GGCT in RBCs is still not clear. Here we reported that Ggct deletion in mouse leads to splenomegaly and progressive anemia phenotypes, due to elevated oxidativ...

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Literature Corpus work: e0151be5-5ec8-5c32-b34c-6ec274f9a726
DOI: 10.1101/2021.06.21.449332

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