Article
Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response.
The FEBS journal - 1 Nov 2016
Biagiotti Sara, Menotta Michele, Orazi Sara, Spapperi Chiara, Brundu Serena, Fraternale Alessandra, Bianchi Marzia, Rossi Luigia, Chessa Luciana, Magnani Mauro
Abstract excerpt
Ataxia telangiectasia (A-T) is a rare incurable neurodegenerative disease caused by biallelic mutations in the gene for ataxia-telangiectasia mutated (ATM). The lack of a functional ATM kinase leads to a pleiotropic phenotype, and oxidative stress is considered to have a crucial role in the complex physiopathology. Recently, steroids have been shown to reduce the neurological symptoms of the disease, although the...
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