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Article

Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.

Cell metabolism - 14 Jun 2016

Roux Antoine E, Langhans Kelley, Huynh Walter, Kenyon Cynthia

Abstract excerpt

Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, decreased proteotoxic-stress resistance, and at the organismal level, decline of mobility and high...

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Identifiers

PMID: 27304510
DOI: 10.1016/j.cmet.2016.05.024
PMCID: PMC5794336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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