Article
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
Autophagy - 1 Apr 2008
Tóth Márton L, Sigmond Tímea, Borsos Eva, Barna János, Erdélyi Péter, Takács-Vellai Krisztina, Orosz László, Kovács Attila L, Csikós György, Sass Miklós, Vellai Tibor
Abstract excerpt
Aging is a multifactorial process with many mechanisms contributing to the decline. Mutations decreasing insulin/IGF-1 (insulin-like growth factor-1) or TOR (target of rapamycin) kinase-mediated signaling, mitochondrial activity and food intake each extend life span in divergent animal phyla. Understanding how these genetically distinct mechanisms interact to control longevity is a fundamental and fascinating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.