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Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage

8 Apr 2025

Abstract excerpt

To maintain tissue homeostasis, many cells reside in a quiescent state until prompted to divide. The reactivation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfolded protein response regulators IRE-1 and XBP-1 are required for the reactivation of quiescent cells in developmentally L1-arrested C. elegans. Utilizing a forward genetic screen in C....

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PMID: 40203825
DOI: 10.1016/j.cell.2025.03.009

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