Article
Evaluation of cytochrome P450 2C9 activity in normal, healthy, adult Western Indian population by both phenotyping and genotyping.
Indian journal of pharmacology - 1 Jan 2000
Swar Balkrishna D, Bendkhale Shital R, Rupawala Abbas, Sridharan Kannan, Gogtay Nithya J, Thatte Urmila M, Kshirsagar Nilima A
Abstract excerpt
OBJECTIVES: Cytochrome P450 2C9 (CYP2C9) is a member of cytochrome P450 (CYP) family that accounts for nearly 18% of the total CYP protein content in the human liver microsomes and catalyzes almost 15-20% of the drugs. Considering the paucity of data on the polymorphisms of CYP2C9 in Western Indian population, the present study was conducted to evaluate the prevalence of CYP2C9 polymorphisms (*1, *2 and *3) and...
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