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Major Allele Frequencies in <em>CYP2C9</em> and <em>CYP2C19</em> in Asian and European Populations: A Case Study to Disaggregate Data Among Large Racial Categories

2025-05-29

Abstract excerpt

CYP2C9 and CYP2C19 are major CYP450 enzymes that heavily influence the hepatic metabolism and bioactivation of many medications, including over-the-counter and narrow therapeutic index drugs. Compared to the wild-type alleles, genetic variants in either gene can potentially alter the pharmacokinetics of widely used medications, affect the desired therapeutic outcomes of a drug therapy, or increase the risk of unde...

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Literature Corpus work
f1781ef2-4367-5142-8d8c-224cc7eabc36
DOI
10.20944/preprints202505.2348.v1
Open publication

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