Article
Cytochrome P450 2C19 enzyme, Cytochrome P450 2C9 enzyme, and Cytochrome P450 2D6 enzyme allelic variants and its possible effect on drug metabolism: A retrospective study.
Medicine - 19 Mar 2021
Naujokaitis Domas, Asmoniene Virginija, Kadusevicius Edmundas
Abstract excerpt
ABSTRACT: The objective of the present study was to assess the allelic variations of Cytochrome P450 (CYP) enzymes Cytochrome P450 2C19 (CYP2C19), Cytochrome P450 2C9 (CYP2C9), and Cytochrome P450 2D6 (CYP2D6) as they play a major role in drug metabolism. The interindividual genetic variabilities of these enzymes can account for different responsiveness as well as concentration fluctuations for a particular...
Topics
- Alleles
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP2D6
- Genotype
- Humans
- Lithuania
- Liver
- Pharmaceutical Preparations
- Pharmacogenomic Testing
- Pharmacogenomic Variants