Article
Evaluation of the activity of CYP2C19 in Gujrati and Marwadi subjects living in Mumbai (Bombay).
BMC clinical pharmacology - 24 Oct 2006
Panchabhai Tanmay S, Noronha Shaun F, Davis Sanish, Shinde Vishal M, Kshirsagar Nilima A, Gogtay Nithya J
Abstract excerpt
BACKGROUND: Inherited differences in the metabolism and disposition of drugs, and genetic polymorphisms in the targets of drug therapy (e.g., receptors), can greatly influence efficacy and toxicity of medications. Marked interethnic differences in CYP2C19 (a member of the cytochrome P-450 enzyme...
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