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Article

Accuracy of Answers to Cell Lineage Questions Depends on Single-Cell Genomics Data Quality and Quantity.

PLoS computational biology - 1 Jun 2016

Spiro Adam, Shapiro Ehud

Abstract excerpt

Advances in single-cell (SC) genomics enable commensurate improvements in methods for uncovering lineage relations among individual cells, as determined by phylogenetic analysis of the somatic mutations harbored by each cell. Theoretically, complete and accurate knowledge of the genome of each cell of an individual can produce an extremely accurate cell lineage tree of that individual. However, the reality of SC...

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PMID: 27295404
DOI: 10.1371/journal.pcbi.1004983
PMCID: PMC4905655

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