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Article

Genomic variability within an organism exposes its cell lineage tree.

PLoS computational biology - 1 Oct 2005

Frumkin Dan, Wasserstrom Adam, Kaplan Shai, Feige Uriel, Shapiro Ehud

Abstract excerpt

What is the lineage relation among the cells of an organism? The answer is sought by developmental biology, immunology, stem cell research, brain research, and cancer research, yet complete cell lineage trees have been reconstructed only for simple organisms such as Caenorhabditis elegans. We discovered that somatic mutations accumulated during normal development of a higher organism implicitly encode its entire...

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Identifiers

PMID: 16261192
DOI: 10.1371/journal.pcbi.0010050
PMCID: PMC1274291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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