Article
Spatially interacting phosphorylation sites and mutations in cancer.
Nature communications - 19 Apr 2021
Huang Kuan-Lin, Scott Adam D, Zhou Daniel Cui, Wang Liang-Bo, Weerasinghe Amila, Elmas Abdulkadir, Liu Ruiyang, Wu Yige, Wendl Michael C, Wyczalkowski Matthew A, Baral Jessika, Sengupta Sohini, Lai Chin-Wen, Ruggles Kelly, Payne Samuel H, Raphael Benjamin, Fenyö David, Chen Ken, Mills Gordon, Ding Li
Abstract excerpt
Advances in mass-spectrometry have generated increasingly large-scale proteomics datasets containing tens of thousands of phosphorylation sites (phosphosites) that require prioritization. We develop a bioinformatics tool called HotPho and systematically discover 3D co-clustering of phosphosites and cancer mutations on protein structures. HotPho identifies 474 such hybrid clusters containing 1255 co-clustering...
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