Article

Spatially Interacting Phosphorylation Sites and Mutations in Cancer

2021-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Advances in mass-spectrometry have generated increasingly large-scale proteomics datasets containing tens of thousands of phosphorylation sites (phosphosites) that require prioritization. We develop a bioinformatics tool called HotPho and systematically discover 3D co-clustering of phosphosites and cancer mutations on protein structures. HotPho identifies 474 such hybrid clusters containing 1,25...

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Literature Corpus work: 993fd4af-0839-5ee6-a02e-3d7a895c0c49
DOI: 10.1101/2021.02.14.431184

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