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Article

Pan-Cancer Landscape of Spatial PTM and Mutation Clusters Reveals Allosteric Regulation of Protein-Protein Interactions.

Journal of chemical information and modeling - 10 Aug 2026

Luo Dongfang, Zheng Jiani, Du Xikun, Xia Danni, Zhang Meng, Liang Zhongjie

Abstract excerpt

Post-translational modifications (PTMs) and somatic mutations are pervasive in cancer, yet their three-dimensional organization and coordinated regulatory mechanisms within protein-protein interactions (PPIs) remain poorly understood. Here we develop ClusTar, a structural framework that systematically identifies spatial clusters of PTMs and mutations within PPIs and links them to protein dynamics and functional...

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PMID: 42467519
DOI: 10.1021/acs.jcim.6c01767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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