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Article

Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype.

Biomaterials - 1 Oct 2021

Tan Xiaohong, Jain Era, Barcellona Marcos N, Morris Evan, Neal Sydney, Gupta Munish C, Buchowski Jacob M, Kelly Michael, Setton Lori A, Huebsch Nathaniel

Abstract excerpt

Biomaterial based strategies have been widely explored to preserve and restore the juvenile phenotype of cells of the nucleus pulposus (NP) in degenerated intervertebral discs (IVD). With aging and maturation, NP cells lose their ability to produce necessary extracellular matrix and proteoglycans, accelerating disc degeneration. Previous studies have shown that integrin or syndecan binding peptide motifs from...

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Identifiers

PMID: 34492582
DOI: 10.1016/j.biomaterials.2021.121113
PMCID: PMC9107941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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