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Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells

9 Mar 2018

Abstract excerpt

BACKGROUND: Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based IVD therapy has emerged as an area of great interest, with studies reporting regenerative potential for many cell sources, including autologous or allogeneic...

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PMID: 29523190
DOI: 10.1186/s13287-018-0797-1

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