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Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc

21 Aug 2018

Abstract excerpt

The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is thought to contribute to the onset of intervertebral disc degeneration. Thus, defining the phenotype of human embryonic/fetal notochordal cells is essential for understanding their roles and for development of novel therapies. However, a detailed transcriptomic profiling of human...

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PMID: 30150762
DOI: 10.1038/s41598-018-31172-4

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