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CD24 Positive Nucleus Pulposus Cells in Adult Human Intervertebral Discs Maintain a More Notochordal Phenotype Than GD2 Positive Cells

1 Dec 2024

Abstract excerpt

ABSTRACT Background Notochordal cells (NCs) present in the nucleus pulposus (NP) of the developing human intervertebral disc (IVD) disappear during the first decade of life. This loss coincides with the onset of IVD degeneration, therefore these cells are hypothesized to be important in NP homeostasis. Putative NC‐derived (CD24+) and progenitor (TIE2+/GD2+) cell sub‐populations have previously been identified in...

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PMID: 39717383
DOI: 10.1002/jsp2.70029

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