Article
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
Oncogene - 17 Nov 2016
Werden S J, Sphyris N, Sarkar T R, Paranjape A N, LaBaff A M, Taube J H, Hollier B G, Ramirez-Peña E Q, Soundararajan R, den Hollander P, Powell E, Echeverria G V, Miura N, Chang J T, Piwnica-Worms H, Rosen J M, Mani S A
Abstract excerpt
Metastatic competence is contingent upon the aberrant activation of a latent embryonic program, known as the epithelial-mesenchymal transition (EMT), which bestows stem cell properties as well as migratory and invasive capabilities upon differentiated tumor cells. We recently identified the transcription factor FOXC2 as a downstream effector of multiple EMT programs, independent of the EMT-inducing stimulus, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.