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Article

Tenascin C in metastasis: A view from the invasive front

2 Jan 2015

Abstract excerpt

The extracellular matrix protein tenascin C (TNC) is a large glycoprotein expressed in connective tissues and stem cell niches. TNC over-expression is repeatedly observed in cancer, often at the invasive tumor front, and is associated with poor clinical outcome in several malignancies. The link between TNC expression and poor survival in cancer patients suggests a role for TNC in metastatic progression, which is...

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Identifiers

PMID: 25738825
DOI: 10.1080/19336918.2015.1008331

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