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ERK1/2 Regulation of CD44 Modulates Oral Cancer Aggressiveness

16 Nov 2011

Abstract excerpt

Carcinogen-induced oral cavity squamous cell carcinoma (OSCC) incurs significant morbidity and mortality and constitutes a global health challenge. To gain further insight into this disease, we generated cell line models from 7,12-dimethylbenz(a)anthracene-induced murine primary OSCC capable of tumor formation upon transplantation into immunocompetent wild-type mice. Whereas several cell lines grew rapidly and...

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PMID: 22086849
DOI: 10.1158/0008-5472.can-11-1831

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