Article
Intracellular IL-37b interacts with Smad3 to suppress multiple signaling pathways and the metastatic phenotype of tumor cells.
Oncogene - 18 May 2017
Luo C, Shu Y, Luo J, Liu D, Huang D-S, Han Y, Chen C, Li Y-C, Zou J-M, Qin J, Wang Y, Li D, Wang S-S, Zhang G-M, Chen J, Feng Z-H
Abstract excerpt
Multiple signaling pathways that promote tumor cell metastasis are differentially activated in low/non-metastatic and metastatic tumor cells, resulting in the differential expression of metastasis-related genes. The underlying mechanism may involve the alterations of the intrinsic negative regulation in tumor cells. Here we report that the differential expression of interleukin-37b (IL-37b) in tumor cells alters...
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