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Article

Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling.

Molecular cancer research : MCR - 1 Feb 2021

Dwyer Amy R, Kerkvliet Carlos Perez, Krutilina Raisa I, Playa Hilaire C, Parke Deanna N, Thomas Warner A, Smeester Branden A, Moriarity Branden S, Seagroves Tiffany N, Lange Carol A

Abstract excerpt

Protein tyrosine kinase 6 (PTK6; also called Brk) is overexpressed in 86% of patients with breast cancer; high PTK6 expression predicts poor outcome. We reported PTK6 induction by HIF/GR complexes in response to either cellular or host stress. However, PTK6-driven signaling events in the context of triple-negative breast cancer (TNBC) remain undefined. In a mouse model of TNBC, manipulation of PTK6 levels (i.e.,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33172975
DOI: 10.1158/1541-7786.MCR-20-0295
PMCID: PMC7951948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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