Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchyme Forkhead 1 ( <i>FOXC2</i> ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

30 May 2007

Abstract excerpt

The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics the cell migrations that occur during embryogenesis. Using gene expression profiling, we have found that the FOXC2 transcription factor, which is involved in specifying mesenchymal cell fate during embryogenesis, is associated with the metastatic capabilities of cancer cells. FOXC2 expression is required for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to FOXO transcription factor regulation
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17537911
DOI: 10.1073/pnas.0703900104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchyme Forkhead 1 ( <i>FOXC2</i> ) plays a key role in metastasis and is associated with aggressive basal-like breast cancersPMID 17537911Read ↗

FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer.Semantic proximity Read ↗

<i>Foxc1</i> controls cell fate decisions during transforming growth factor β induced epithelial to mesenchymal transition through the regulation of fibroblast growth factor receptor 1 expressionSemantic proximity Read ↗

FOXC1 Regulates FGFR1 Isoform Switching to Promote Invasion Following TGFβ-Induced EMTSemantic proximity Read ↗

A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancerSemantic proximity Read ↗

FOXF2 reprograms breast cancer cells into bone metastasis seedsSemantic proximity Read ↗

FOXF2 suppresses the FOXC2-mediated epithelial-mesenchymal transition and multidrug resistance of basal-like breast cancer.Semantic proximity Read ↗

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast CancerSemantic proximity Read ↗

FBLN2 is associated with basal cell markers Krt14 and ITGB1 in mouse mammary epithelial cells and has a preferential expression in molecular subtypes of human breast cancerSemantic proximity Read ↗

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progressionSemantic proximity Read ↗

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transitionSemantic proximity Read ↗

Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer MetastasisSemantic proximity Read ↗

FOXQ1 Regulates Epithelial-Mesenchymal Transition in Human CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.