Article
Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.
Oncogene - 23 Jun 2016
Wang H, Liu B, Al-Aidaroos A Q O, Shi H, Li L, Guo K, Li J, Tan B C P, Loo J M, Tang J P, Thura M, Zeng Q
Abstract excerpt
Despite abundant data supporting c-Src as a metastasis-promoting oncogene, activating mutations of c-Src are rare. This suggests that trans-interacting proteins may have a critical role in regulating c-Src activation. Here, we first report the discovery of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL), a novel c-Src activator in mice. Ectopic expression of murine SH3BGRL (mSH3BGRL)...
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