Article
Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics.
Nucleic acids research - 21 Aug 2017
Clay Mary C, Ganser Laura R, Merriman Dawn K, Al-Hashimi Hashim M
Abstract excerpt
Recent studies have shown that RNAs exist in dynamic equilibrium with short-lived low-abundance 'excited states' that form by reshuffling base pairs in and around non-canonical motifs. These conformational states are proposed to be rich in non-canonical motifs and to play roles in the folding and regulatory functions of non-coding RNAs but their structure proves difficult to characterize given their transient...
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