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Article

Trapped water molecules are essential to structural dynamics and function of a ribozyme.

Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006

Rhodes Maria M, Réblová Kamila, Sponer Jirí, Walter Nils G

Abstract excerpt

Ribozymes are catalytically competent examples of highly structured noncoding RNAs, which are ubiquitous in the processing and regulation of genetic information. Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural...

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Identifiers

PMID: 16938834
DOI: 10.1073/pnas.0605090103
PMCID: PMC1569172

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