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Article

Pins is not required for spindle orientation in the Drosophila wing disc.

Development (Cambridge, England) - 15 Jul 2016

Bergstralh Dan T, Lovegrove Holly E, Kujawiak Izabela, Dawney Nicole S, Zhu Jinwei, Cooper Samantha, Zhang Rongguang, St Johnston Daniel

Abstract excerpt

In animal cells, mitotic spindles are oriented by the dynein/dynactin motor complex, which exerts a pulling force on astral microtubules. Dynein/dynactin localization depends on Mud/NUMA, which is typically recruited to the cortex by Pins/LGN. In Drosophila neuroblasts, the Inscuteable/Baz/Par-6/aPKC complex recruits Pins apically to induce vertical spindle orientation, whereas in epithelial cells Dlg recruits...

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Identifiers

PMID: 27287805
DOI: 10.1242/dev.135475
PMCID: PMC4958339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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