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Article

Role of inscuteable in orienting asymmetric cell divisions in Drosophila.

Nature - 5 Sept 1996

Kraut R, Chia W, Jan L Y, Jan Y N, Knoblich J A

Abstract excerpt

Drosophila neuroblasts and epithelial cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell. We demonstrate here that orientation of the mitotic spindle and correct localization of Numb and Prospero in these cells require the inscuteable gene. Moreover, ectopic expression of inscuteable in other epithelial cells...

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PMID: 8779714
DOI: 10.1038/383050a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of inscuteable in orienting asymmetric cell divisions in Drosophila.PMID 8779714Read ↗

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Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release.Semantic proximity Read ↗

Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.Semantic proximity Read ↗

Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions.Semantic proximity Read ↗

Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis.Semantic proximity Read ↗

miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis.Semantic proximity Read ↗

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Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

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