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Article

A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes

6 Jul 2015

Abstract excerpt

Assembly of a bipolar microtubule spindle is essential for accurate chromosome segregation. In somatic cells, spindle bipolarity is determined by the presence of exactly two centrosomes. Remarkably, mammalian oocytes do not contain canonical centrosomes. This study reveals that mouse oocytes assemble a bipolar spindle by fragmenting multiple acentriolar microtubule-organizing centres (MTOCs) into a high number of...

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PMID: 26147444
DOI: 10.1038/ncomms8217

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