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Article

Mechanisms of minor pole-mediated spindle bipolarization in human oocytes.

Science (New York, N.Y.) - 23 Aug 2024

Wu Tianyu, Luo Yuxi, Zhang Meiling, Chen Biaobang, Du Xingzhu, Gu Hao, Xie Siyuan, Pan Zhiqi, Yu Ran, Hai Ruiqi, Niu Xiangli, Hao Guimin, Jin Liping, Shi Juanzi, Sun Xiaoxi, Kuang Yanping, Li Wen, Sang Qing, Wang Lei

Abstract excerpt

Spindle bipolarization, the process of a microtubule mass transforming into a bipolar spindle, is a prerequisite for accurate chromosome segregation. In contrast to mitotic cells, the process and mechanism of spindle bipolarization in human oocytes remains unclear. Using high-resolution imaging in more than 1800 human oocytes, we revealed a typical state of multipolar intermediates that form during spindle...

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PMID: 39172836
DOI: 10.1126/science.ado1022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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