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Article

Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.

Molecular biology of the cell - 1 Jun 2012

Althoff Friederike, Karess Roger E, Lehner Christian F

Abstract excerpt

Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes. Moreover, Mps1 kinase contributes in a SAC-independent manner to the correction of erroneous initial attachments of chromosomes to the spindle. Our characterization of the Drosophila homologue reveals yet another SAC-independent role. As in yeast, modest...

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Identifiers

PMID: 22553353
DOI: 10.1091/mbc.E12-02-0117
PMCID: PMC3374747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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