Article
CNDP1 genotype and renal survival in pediatric nephropathies.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jul 2016
Peters Verena, Kebbewar Moustafa, Janssen Bart, Hoffmann Georg F, Möller Kristina, Wygoda Simone, Charbit Marina, Fernandes-Teixeira Ana, Jeck Nikola, Zschocke Johannes, Schmitt Claus Peter, Schäfer Franz, Wühl Elke
Abstract excerpt
BACKGROUND: The risk of developing type II diabetic nephropathy (DN) is lower in patients carrying the CNDP1 Mannheim polymorphism (homozygosity for the five leucine repeat), resulting in decreased activity of the histidine-dipeptide metabolizing enzyme carnosinase. The role of CNDP1 in other nephropathies is still unknown. METHODS: To evaluate the impact of the CNDP1 Mannheim allele on pediatric chronic kidney...
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