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Article

Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.

Journal of inherited metabolic disease - 1 Jan 2018

Peters Verena, Zschocke Johannes, Schmitt Claus P

Abstract excerpt

Carnosinase (CN1) is a dipeptidase, encoded by the CNDP1 gene, that degrades histidine-containing dipeptides, such as carnosine, anserine and homocarnosine. Loss of CN1 function (also called carnosinase deficiency or aminoacyl-histidine dipeptidase deficiency) has been reported in a small number of patients with highly elevated blood carnosine concentrations, denoted carnosinaemia; it is unclear whether the...

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Identifiers

PMID: 29027595
DOI: 10.1007/s10545-017-0099-2

Genes

CNDP1

Provenance

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Related research

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Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.PMID 29027595Read ↗

CNDP1 and Diabetic Kidney Disease: From Genetic Susceptibility to Therapeutic Targeting.Semantic proximity Read ↗

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Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.Semantic proximity Read ↗

Genetic Polymorphisms of Carnosine Synthase -1(ATPGD1) and Serum Carnosine Levels in Relation to Cardio Vascular Diseases in Iraqi Type 2 DiabeticsSemantic proximity Read ↗

Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease.Semantic proximity Read ↗

Serum Carnosinase-1 and Albuminuria Rather than the CNDP1 Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.Semantic proximity Read ↗

A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.Semantic proximity Read ↗

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine productionSemantic proximity Read ↗

Association between CNDP1 genotype and diabetic nephropathy is sex specific.Semantic proximity Read ↗

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