Article
A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.
Diabetologia - 1 Dec 2010
Alkhalaf A, Bakker S J L, Bilo H J G, Gans R O B, Navis G J, Postmus D, Forsblom C, Groop P H, Vionnet N, Hadjadj S, Marre M, Parving H H, Rossing P, Tarnow L
Abstract excerpt
AIMS/HYPOTHESIS: Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality;...
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