Article
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Diabetes - 1 Aug 2005
Janssen Bart, Hohenadel Daniela, Brinkkoetter Paul, Peters Verena, Rind Nina, Fischer Christine, Rychlik Ivan, Cerna Marie, Romzova Marianna, de Heer Emile, Baelde Hans, Bakker Stephan J L, Zirie Mahmoud, Rondeau Eric, Mathieson Peter, Saleem Moin A, Meyer Jochen, Köppel Hannes, Sauerhoefer Sibylle, Bartram Claus R, Nawroth Peter, Hammes Hans-Peter, Yard Benito A, Zschocke Johannes, van der Woude Fokko J
Abstract excerpt
The risk of diabetic nephropathy is partially genetically determined. Diabetic nephropathy is linked to a gene locus on chromosome 18q22.3-q23. We aimed to identify the causative gene on chromosome 18 and to study the mechanism by which the product of this gene could be involved in the development of diabetic nephropathy. DNA polymorphisms were determined in 135 case (diabetic nephropathy) and 107 control...
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